NFL Season Week 2 Previews, Odds, and Picks Week 2 of the NFL season is here, and after an exciting opening week. We have another loaded Sunday schedule followed by Monday Night Football. Thursday’s Lions versus Bills game is already final (Bills 41, Lions 31), so this focuses on the remaining slate. Here are my picks for every NFL Week 2 Sunday and Monday game, including the current odds, a quick preview, and the Bystander picks.

NFL Season Week 1 Previews, Odds, and Picks I'm taking a quick look at every matchup for week 1, giving a preview, the current betting odds, what I think will decide each game and most importantly give The Bystander Pick. These aren't just picks based on who is favored. I'm looking at the matchup, how each team can win, where I think one team has an advantage and what could ultimately decide the game.

The Jacksonville Jaguars are coming off a division-winning season. The Houston Texans are trying to reclaim the AFC South after finishing 12-5 in 2025. The Indianapolis Colts are looking to bounce back after a promising start to last season disappeared down the stretch. And the Tennessee Titans are hoping their young roster takes a major step forward.

The Baltimore Ravens are trying to bounce back from an 8-9 season. The Cincinnati Bengals are looking to return to the playoffs after missing them for three straight seasons. The Pittsburgh Steelers are coming off an AFC North championship and are hoping to prove last season was the beginning of something bigger. Meanwhile, the Cleveland Browns are entering a new era under head coach Todd Monken. On paper, there is a legitimate argument for all four teams.

The Buffalo Bills spent five consecutive seasons winning the division before the New England Patriots finally knocked them off in 2025. New England went 14-3 and reached Super Bowl LX, while Buffalo finished 12-5 and reached the divisional round. Now, heading into the 2026 season, the Bills are favored by the oddsmakers to take the division back. And that makes some sense.

The Kansas City Chiefs are looking to bounce back from a disappointing 2025 season. The Denver Broncos are coming off a 14-3 season and their first AFC West title since 2015. The Los Angeles Chargers have one of the league's most talented quarterbacks in Justin Herbert and are hoping a new offensive system can take them to another level. Meanwhile, the Las Vegas Raiders are trying to speed up their rebuild after selecting quarterback Fernando Mendoza with the No. 1 overall pi